KB5068221: addresses an issue that affects Microsoft Office applications

September 22, 2025—KB5068221 (OS Build 26100.6588) Out-of-band

Improvements
This Out-of-band (OOB) update includes quality improvements. This update is cumulative and includes security fixes and improvements from the September 9, 2025, security update (KB5065426), in addition to the following:

• [Virtualization and platform compatibility] Fixed: This update addresses an issue that affects Microsoft Office applications running in Microsoft Application Virtualization (App-V) environments. The failure occurred due to a double handle closure in the AppVEntSubsystems32 or AppVEntSubsystems64 system component.

AI Components
This release updates the following AI components:

• Image Search : 1.2508.906.0
• Content Extraction: 1.2508.906.0
• Semantic Analysis : 1.2508.906.0
• Settings Model: 1.2508.906.0